Drug Information

Drug General Information
Drug ID
D0BB0O
Former ID
DIB018560
Drug Name
2MeSADP
Synonyms
2-methylthio-ADP; 2-MeSADP; 2-methylthio-adenosine-5'-diphosphate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539063]
Structure
Download
2D MOL
Formula
C11H17N5O10P2S
InChI
InChI=1S/C11H17N5O10P2S/c1-29-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(25-10)2-24-28(22,23)26-27(19,20)21/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,23)(H2,12,14,15)(H2,19,20,21)/t4-,6-,7-,10-/m1/s1
InChIKey
WLMZTKAZJUWXCB-KQYNXXCUSA-N
PubChem Compound ID
121990
PubChem Substance ID
7978585, 10239899, 14834404, 29302467, 50218522, 57339889, 103366656, 103810802, 104011579, 104414763, 117627056, 129598830, 135255735, 135651125, 135651401, 177013249, 184587770, 226554413
Target and Pathway
Target(s) P2Y purinoceptor 12 Target Info Agonist [527109]
P2Y purinoceptor 1 Target Info Agonist [526444]
P2Y13 receptor Target Info Agonist [526649]
KEGG Pathway Platelet activationhsa04015:Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome P2Y receptors
G alpha (i) signalling eventsR-HSA-416476:G alpha (q) signalling events
ADP signalling through P2Y purinoceptor 1
WikiPathways GPCRs, Class A Rhodopsin-like
Signal amplification
GPCR ligand binding
GPCR downstream signalingWP80:Nucleotide GPCRs
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
References
Ref 539063(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1710).
Ref 526444Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist. Mol Pharmacol. 2002 Nov;62(5):1249-57.
Ref 526649Pharmacological characterization of the human P2Y13 receptor. Mol Pharmacol. 2003 Jul;64(1):104-12.
Ref 527109P2Y12, a new platelet ADP receptor, target of clopidogrel. Semin Vasc Med. 2003 May;3(2):113-22.

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