Drug General Information
Drug ID	D0BI3N
Former ID	DIB006023
Drug Name	Cerdulatinib
Synonyms	PRT-062070; Syk + JAK multikinase inhibitor (NHL/CLL/RA), Portola Pharmaceuticals
Indication	Non-hodgkin's lymphoma [ICD10:C85]		Phase 1/2	[551978]
Company	Portola Pharmaceuticals Inc; portola pharmaceuticals
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Tyrosine-protein kinase JAK2	Target Info	Modulator
	Tyrosine-protein kinase SYK	Target Info	Modulator
KEGG Pathway	Chemokine signaling pathway
	PI3K-Akt signaling pathway
	Signaling pathways regulating pluripotency of stem cells
	Jak-STAT signaling pathway
	Cholinergic synapse
	Prolactin signaling pathway
	Adipocytokine signaling pathway
	Leishmaniasis
	Toxoplasmosis
	Tuberculosis
	Measles
	Influenza A
	Herpes simplex infectionhsa04064:NF-kappa B signaling pathway
	Osteoclast differentiation
	Platelet activation
	Natural killer cell mediated cytotoxicity
	B cell receptor signaling pathway
	Fc epsilon RI signaling pathway
	Fc gamma R-mediated phagocytosis
	Epstein-Barr virus infection
	Viral carcinogenesis
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
	Interferon-gamma signaling pathway
	JAK/STAT signaling pathway
	PDGF signaling pathway
	PI3 kinase pathway
	CCKR signaling map STP00010:B cell activation
Pathway Interaction Database	Endothelins
	ErbB4 signaling events
	GMCSF-mediated signaling events
	IL4-mediated signaling events
	IL27-mediated signaling events
	Signaling events mediated by PTP1B
	IL12-mediated signaling events
	S1P3 pathway
	SHP2 signaling
	CXCR4-mediated signaling events
	IL5-mediated signaling events
	IFN-gamma pathway
	ErbB2/ErbB3 signaling events
	IL3-mediated signaling events
	IL6-mediated signaling events
	PDGFR-beta signaling pathway
	IL23-mediated signaling events
	Signaling events mediated by Stem cell factor receptor (c-Kit)
	EPO signaling pathway
	Notch-mediated HES/HEY networkfcer1pathway:Fc-epsilon receptor I signaling in mast cells
	BCR signaling pathway
	Atypical NF-kappaB pathway
	Osteopontin-mediated events
	FAS (CD95) signaling pathway
	Thromboxane A2 receptor signaling
	IL2-mediated signaling events
	Class I PI3K signaling events
	Alpha-synuclein signaling
PathWhiz Pathway	Fc Epsilon Receptor I Signaling in Mast Cells
Reactome	Interleukin-6 signaling
	MAPK3 (ERK1) activation
	MAPK1 (ERK2) activation
	GPVI-mediated activation cascade
	Prolactin receptor signaling
	RMTs methylate histone arginines
	G beta:gamma signalling through PI3Kgamma
	Interleukin-3, 5 and GM-CSF signaling
	RAF activation
	RAF/MAP kinase cascade
	Interferon gamma signaling
	Regulation of IFNG signaling
	Interleukin receptor SHC signaling
	Growth hormone receptor signaling
	Factors involved in megakaryocyte development and platelet productionR-HSA-114604:GPVI-mediated activation cascade
	FCGR activation
	Regulation of actin dynamics for phagocytic cup formation
	Role of phospholipids in phagocytosis
	DAP12 signaling
	Fc epsilon receptor (FCERI) signaling
	Role of LAT2/NTAL/LAB on calcium mobilization
	FCERI mediated MAPK activation
	FCERI mediated Ca+2 mobilization
	Integrin alphaIIb beta3 signaling
	Interleukin-2 signaling
	CLEC7A (Dectin-1) signaling
	Dectin-2 family
	Regulation of signaling by CBL
	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
WikiPathways	Serotonin Receptor 2 and STAT3 Signaling
	Type II interferon signaling (IFNG)
	Notch Signaling Pathway
	EPO Receptor Signaling
	EGF/EGFR Signaling Pathway
	IL-4 Signaling Pathway
	IL-6 signaling pathway
	Kit receptor signaling pathway
	IL-3 Signaling Pathway
	Mesodermal Commitment Pathway
	Interleukin-2 signaling
	Signaling by SCF-KIT
	Prolactin receptor signaling
	Growth hormone receptor signaling
	JAK/STAT
	BDNF signaling pathway
	Oncostatin M Signaling Pathway
	Interleukin-11 Signaling Pathway
	AGE/RAGE pathway
	TSLP Signaling Pathway
	IL17 signaling pathway
	Leptin signaling pathway
	TSH signaling pathway
	Interleukin-3, 5 and GM-CSF signaling
	Interferon gamma signaling
	Factors involved in megakaryocyte development and platelet production
	IL-5 Signaling PathwayWP49:IL-2 Signaling Pathway
	Fc epsilon receptor (FCERI) signaling
	Signaling by the B Cell Receptor (BCR)
	Fcgamma receptor (FCGR) dependent phagocytosis
	DAP12 interactions
	B Cell Receptor Signaling Pathway
	RANKL/RANK Signaling Pathway
	Integrin alphaIIb beta3 signaling
	GPVI-mediated activation cascade
	Regulation of toll-like receptor signaling pathway
	IL-5 Signaling Pathway
References
Ref 551978	Clinical pipeline report, company report or official report of Portola.

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