| Drug General Information |
| Drug ID |
D0BS6R
|
| Former ID |
DNC004381
|
| Drug Name |
A-420983
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C33H39N9O2
|
| Canonical SMILES |
CN1CCN(CC1)C2CCC(CC2)N3C4=C(C(=N3)C5=CC(=C(C=C5)NC(=O)C<br />6=CC7=CC=CC=C7N6C)OC)C(=NC=N4)N
|
| InChI |
1S/C33H39N9O2/c1-39-14-16-41(17-15-39)23-9-11-24(12-10-23)42-32-29(31(34)35-20-36-32)30(38-42)22-8-13-25(28(19-22)44-3)37-33(43)27-18-21-6-4-5-7-26(21)40(27)2/h4-8,13,18-20,23-24H,9-12,14-17H2,1-3H3,(H,37,43)(H2,34,35,36)
|
| InChIKey |
STVKLDUINKMZFE-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Angiopoietin 1 receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Proto-oncogene tyrosine-protein kinase SRC |
Target Info |
Inhibitor |
[1]
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| Lck tyrosine kinase |
Target Info |
Inhibitor |
[1]
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KEGG Pathway
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Ras signaling pathway
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Rap1 signaling pathway
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HIF-1 signaling pathway
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PI3K-Akt signaling pathway
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Rheumatoid arthritishsa04012:ErbB signaling pathway
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Chemokine signaling pathway
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Endocytosis
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VEGF signaling pathway
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Focal adhesion
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Adherens junction
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Tight junction
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Gap junction
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Platelet activation
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GABAergic synapse
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Inflammatory mediator regulation of TRP channels
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Regulation of actin cytoskeleton
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GnRH signaling pathway
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Estrogen signaling pathway
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Prolactin signaling pathway
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Thyroid hormone signaling pathway
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Oxytocin signaling pathway
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Bacterial invasion of epithelial cells
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Epithelial cell signaling in Helicobacter pylori infection
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Shigellosis
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Tuberculosis
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Hepatitis B
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Viral carcinogenesis
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Proteoglycans in cancerhsa04064:NF-kappa B signaling pathway
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Osteoclast differentiation
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Natural killer cell mediated cytotoxicity
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T cell receptor signaling pathway
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HTLV-I infection
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Primary immunodeficiency
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NetPath Pathway
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Wnt Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_11:TCR Signaling Pathway
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IL2 Signaling Pathway
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PANTHER Pathway
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AngiogenesisP00005:Angiogenesis
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Cadherin signaling pathway
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Integrin signalling pathway
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Parkinson disease
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CCKR signaling map STP00049:Parkinson disease
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T cell activation
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Pathway Interaction Database
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Angiopoietin receptor Tie2-mediated signaling
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SHP2 signalingendothelinpathway:Endothelins
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Signaling events mediated by PRL
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LPA receptor mediated events
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Atypical NF-kappaB pathway
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Glypican 1 network
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Plasma membrane estrogen receptor signaling
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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Signaling events mediated by PTP1B
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S1P3 pathway
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EPHB forward signaling
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Nectin adhesion pathway
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Regulation of p38-alpha and p38-beta
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CDC42 signaling events
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Signaling events regulated by Ret tyrosine kinase
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Arf6 signaling events
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Signaling events mediated by TCPTP
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FAS (CD95) signaling pathway
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Thromboxane A2 receptor signaling
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Netrin-mediated signaling events
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Alpha9 beta1 integrin signaling events
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CXCR4-mediated signaling events
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EGF receptor (ErbB1) signaling pathway
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Class I PI3K signaling events
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Posttranslational regulation of adherens junction stability and dissassembly
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Regulation of Androgen receptor activity
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E-cadherin signaling in the nascent adherens junction
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amb2 Integrin signaling
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Integrins in angiogenesis
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ErbB1 downstream signaling
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
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ErbB2/ErbB3 signaling events
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EPHA forward signaling
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E-cadherin signaling in keratinocytes
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PDGFR-beta signaling pathway
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Nongenotropic Androgen signaling
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Internalization of ErbB1
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CXCR3-mediated signaling events
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Signaling events mediated by VEGFR1 and VEGFR2
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Syndecan-2-mediated signaling events
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Class I PI3K signaling events mediated by Akt
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Syndecan-3-mediated signaling events
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Ephrin B reverse signaling
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Trk receptor signaling mediated by PI3K and PLC-gamma
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EPHA2 forward signaling
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Alpha-synuclein signaling
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FGF signaling pathway
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Alpha4 beta1 integrin signaling events
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Signaling events mediated by focal adhesion kinasenfkappabatypicalpathway:Atypical NF-kappaB pathway
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TCR signaling in naï
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IL12-mediated signaling events
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TCR signaling in naï
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SHP2 signaling
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IL2-mediated signaling events
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IL2 signaling events mediated by PI3K
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IL2 signaling events mediated by STAT5
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Reactome
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Tie2 Signaling
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RAF/MAP kinase cascadeR-HSA-114604:GPVI-mediated activation cascade
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PIP3 activates AKT signaling
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Regulation of KIT signaling
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Phosphorylation of CD3 and TCR zeta chains
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Translocation of ZAP-70 to Immunological synapse
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Generation of second messenger molecules
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PECAM1 interactions
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Constitutive Signaling by Aberrant PI3K in Cancer
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DAP12 signaling
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CD28 co-stimulation
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CD28 dependent PI3K/Akt signaling
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CD28 dependent Vav1 pathway
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CTLA4 inhibitory signaling
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PD-1 signaling
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Interleukin-2 signaling
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WikiPathways
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Wnt Signaling Pathway Netpath
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Cell surface interactions at the vascular wall
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AngiogenesisWP673:ErbB Signaling Pathway
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Senescence and Autophagy in Cancer
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Notch Signaling Pathway
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EPO Receptor Signaling
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EGF/EGFR Signaling Pathway
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TGF beta Signaling Pathway
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Signaling of Hepatocyte Growth Factor Receptor
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Kit receptor signaling pathway
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Pregnane X Receptor pathway
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Aryl Hydrocarbon Receptor Pathway
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IL-3 Signaling Pathway
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Nanoparticle-mediated activation of receptor signaling
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Polycystic Kidney Disease Pathway
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Alpha 6 Beta 4 signaling pathway
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BDNF signaling pathway
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Integrated Pancreatic Cancer Pathway
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Oncostatin M Signaling Pathway
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Interleukin-11 Signaling Pathway
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AGE/RAGE pathway
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Signaling Pathways in Glioblastoma
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TSLP Signaling Pathway
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Arylhydrocarbon receptor (AhR) signaling pathway
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Regulation of Microtubule Cytoskeleton
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FSH signaling pathway
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Leptin signaling pathway
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RANKL/RANK Signaling Pathway
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Integrin-mediated Cell Adhesion
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Angiogenesis
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Androgen receptor signaling pathwayWP61:Notch Signaling Pathway
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Interferon type I signaling pathways
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IL-2 Signaling Pathway
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Inflammatory Response Pathway
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Signaling by SCF-KIT
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DAP12 interactions
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Host Interactions of HIV factors
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PIP3 activates AKT signaling
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T-Cell Receptor and Co-stimulatory Signaling
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B Cell Receptor Signaling Pathway
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TCR signaling
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Costimulation by the CD28 family
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| References |
| REF 1 | Bioorg Med Chem Lett. 2004 May 17;14(10):2613-6.A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection. |
|---|
