Drug General Information
Drug ID	D0BV3J
Former ID	DIB013193
Drug Name	Macimorelin
Synonyms	Solorel; AEZS-130; ARD-07; ARD-0705; EP-01572; EP-1572; JMV-1843
Drug Type	Small molecular drug
Indication	Growth hormone deficiency [ICD9: 253.0, 253.3; ICD10:E22.0, E23.0]		Phase 3	[521987]
Company	Aeterna zentaris
Structure		Download 2D MOL 3D MOL
Formula	C26H30N6O3
Canonical SMILES	c12c(C[C@H](C(=O)N[C@H](Cc3c4c([nH]c3)cccc4)NC=O)NC(=O)<br />C(C)(C)N)c[nH]c1cccc2
CAS Number	CAS 381231-18-1
PubChem Compound ID	9804938
Target and Pathway
Target(s)	Growth hormone secretagogue receptor type 1	Target Info	Agonist	[550490]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
NetPath Pathway	Leptin Signaling Pathway
Reactome	Peptide ligand-binding receptors
	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 521987	ClinicalTrials.gov (NCT00448747) Investigation of a New, Oral Growth Hormone Secretagogue, Macimorelin (AEZS-130) as a Growth Hormone Stimulation Test.. U.S. National Institutes of Health.
Ref 550490	National Cancer Institute Drug Dictionary (drug id 735530).

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