Drug General Information
Drug ID
D0C2HR
Former ID
DIB014459
Drug Name
ORG-9273
Synonyms
1-[(2beta,3alpha,5alpha,16beta,17beta)-17-Acetoxy-3-hydroxy-2-morpholinoandrostan-16-yl]-1-methylpiperidinium bromide; 17beta-Acetoxy-3alpha-hydroxy-16beta-(1-methylhexahydropyridinio-1-yl)-2beta-morpholino-5alpha-androstane bromide
Drug Type
Small molecular drug
Indication Paralysis [ICD10:G72.3] Discontinued in Phase 2 [528223]
Structure
Download
2D MOL

3D MOL

Formula
C31H53N2O4+
Canonical SMILES
CC(=O)OC1C(CC2C1(CCC3C2CCC4C3(CC(C(C4)O)N5CCOCC5)C)C)[N<br />+]6(CCCCC6)C
InChI
1S/C31H53N2O4/c1-21(34)37-29-27(33(4)14-6-5-7-15-33)19-25-23-9-8-22-18-28(35)26(32-12-16-36-17-13-32)20-31(22,3)24(23)10-11-30(25,29)2/h22-29,35H,5-20H2,1-4H3/q+1/t22-,23?,24?,25?,26-,27-,28-,29-,30-,31-/m0/s1
InChIKey
DHYOZTTVCWLBTR-JHKQNVCFSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Nicotinic acetylcholine receptor Target Info Modulator [528223], [551871]
References
Ref 528223Dose-response relation, neuromuscular blocking action, intubation conditions, and cardiovascular effects of Org 9273, a new neuromuscular blocking agent. Anesth Analg. 1991 Jun;72(6):811-6.
Ref 528223Dose-response relation, neuromuscular blocking action, intubation conditions, and cardiovascular effects of Org 9273, a new neuromuscular blocking agent. Anesth Analg. 1991 Jun;72(6):811-6.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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