Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0C3BS
|
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| Former ID |
DNCL003422
|
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| Drug Name |
DU-176b
|
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| Synonyms |
Edoxaban
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| Drug Type |
Small molecular drug
|
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| Company |
Daiichi Sankyo
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C24H30ClN7O4S
|
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| InChI |
InChI=1S/C24H30ClN7O4S/c1-31(2)24(36)13-4-6-15(27-20(33)21(34)30-19-7-5-14(25)11-26-19)17(10-13)28-22(35)23-29-16-8-9-32(3)12-18(16)37-23/h5,7,11,13,15,17H,4,6,8-10,12H2,1-3H3,(H,27,33)(H,28,35)(H,26,30,34)/t13-,15-,17+/m0/s1
|
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| InChIKey |
HGVDHZBSSITLCT-JLJPHGGASA-N
|
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| CAS Number |
CAS 912273-65-5
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
15285745, 22657909, 35552742, 75383420, 109693269, 123092995, 123107846, 124490450, 135263753, 141477305, 152343994, 162198449, 163409416, 163620696, 163686010, 163909302, 170502825, 172096222, 172121849, 185988955, 198981897, 198992538, 223365911, 223397933, 223922733, 226666786, 249273064, 249736672, 249865853, 252090008, 252150280, 252451702, 252552142
|
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| Target and Pathway | |||||
| Target(s) | Coagulation factor Xa | Target Info | Modulator | [543603] | |
| KEGG Pathway | Complement and coagulation cascades | ||||
| PANTHER Pathway | Blood coagulation | ||||
| Pathway Interaction Database | Beta2 integrin cell surface interactions | ||||
| PathWhiz Pathway | Coagulation | ||||
| Reactome | Extrinsic Pathway of Fibrin Clot Formation | ||||
| Intrinsic Pathway of Fibrin Clot Formation | |||||
| Common Pathway of Fibrin Clot Formation | |||||
| Gamma-carboxylation of protein precursors | |||||
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | |||||
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | |||||
| References | |||||
| Ref 524299 | ClinicalTrials.gov (NCT01857622) Safety and Pharmacokinetics Study of DU-176b Administered to Non-valvular Atrial Fibrillation With Severe Renal Impairment. U.S. National Institutes of Health. | ||||
| Ref 542568 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7575). | ||||
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