Drug Information

Drug General Information
Drug ID
D0C5XQ
Former ID
DNC006063
Drug Name
5-MEO-DMT
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538926]
Structure
Download
2D MOL

3D MOL
Formula
C13H18N2O
InChI
InChI=1S/C13H18N2O/c1-15(2)7-6-10-9-14-13-5-4-11(16-3)8-12(10)13/h4-5,8-9,14H,6-7H2,1-3H3
InChIKey
ZSTKHSQDNIGFLM-UHFFFAOYSA-N
PubChem Compound ID
1832
PubChem Substance ID
10507, 396190, 855873, 3133037, 5496810, 8151306, 10502422, 11111436, 11388126, 11536794, 14773502, 24278119, 26751543, 29221031, 46530517, 47291301, 47440455, 47589168, 47810950, 48035331, 48185166, 48259441, 49747340, 49830131, 49983965, 50100273, 50104133, 57321042, 58004968, 76623346, 81040716, 81093165, 85209445, 92265408, 99381478, 103165737, 104298854, 118048564, 124438278, 124749945, 124801106, 124880659, 124880660, 124880661, 124880662, 124999880, 125336666, 126524284, 126566690, 126572697
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Inhibitor [527952]
5-hydroxytryptamine 6 receptor Target Info Inhibitor [528416]
5-hydroxytryptamine 2B receptor Target Info Inhibitor [527952]
5-hydroxytryptamine 2C receptor Target Info Inhibitor [527952]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
cAMP signaling pathway
Serotonergic synapsehsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
References
Ref 538926(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 145).
Ref 527952J Med Chem. 2006 Jan 12;49(1):318-28.1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.
Ref 528416Bioorg Med Chem Lett. 2006 Nov 15;16(22):5832-5. Epub 2006 Aug 30.Interaction of N1-unsubstituted and N1-benzenesulfonyltryptamines at h5-HT6 receptors.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.