Drug General Information
Drug ID	D0CY4V
Former ID	DIB008768
Drug Name	Cetamolol
Synonyms	Betacor; Cetamolol hydrochloride; AI-27303; AY-27303
Drug Type	Small molecular drug
Indication	Angina pectoris [ICD9: 413; ICD10:I20]		Terminated	[544568]
Company	Zeneca Group plc
Structure		Download 2D MOL 3D MOL
Formula	C16H26N2O4
Canonical SMILES	C(=O)(COc1c(OCC(CNC(C)(C)C)O)cccc1)NC
PubChem Compound ID	53698
Target and Pathway
Target(s)	Beta-1 adrenergic receptor	Target Info	Modulator	[532040], [532693]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Adrenergic signaling in cardiomyocytes
	Gap junction
	Salivary secretion
	Dilated cardiomyopathy
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Beta1 adrenergic receptor signaling pathway
PathWhiz Pathway	Muscle/Heart Contraction
Reactome	Adrenoceptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Endothelin Pathways
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544568	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000160)
Ref 532040	Administration of the cyclic peptide COR-1 in humans (phase I study): ex vivo measurements of anti-beta1-adrenergic receptor antibody neutralization and of immune parameters. Eur J Heart Fail. 2012 Nov;14(11):1230-9.
Ref 532693	Comparison of the beta-adrenoceptor affinity and selectivity of cetamolol, atenolol, betaxolol, and ICI-118,551. J Cardiovasc Pharmacol. 1988 Aug;12(2):208-17.

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