Drug General Information
Drug ID
D0D1GV
Former ID
DIB003285
Drug Name
CNS-1237
Indication Cerebrovascular ischaemia [ICD9: 434.91; ICD10:I61-I63] Terminated [545045]
Company
CeNeS Pharmaceuticals Inc
Structure
Download
2D MOL

3D MOL

Canonical SMILES
C(=N)(Nc1c2c(c(cc1)OC)cccc2)Nc1c2c3c(C=Cc3ccc2)cc1
CAS Number
CAS 174232-22-5
Target and Pathway
Target(s) Maxi K potassium channel Target Info Modulator [534454]
KEGG Pathway cGMP-PKG signaling pathway
Vascular smooth muscle contraction
Insulin secretion
Salivary secretion
Pancreatic secretion
Reactome cGMP effects
WikiPathways Potassium Channels
Platelet homeostasis
References
Ref 545045Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001959)
Ref 534454Effects of Ca2+ and Na+ channel inhibitors in vitro and in global cerebral ischaemia in vivo. Eur J Pharmacol. 1997 Aug 6;332(2):121-31.

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