Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0D1YY
|
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| Former ID |
DIB006282
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| Drug Name |
IGN-2098
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| Drug Type |
Small molecular drug
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| Indication | Duodenal ulcers [ICD10:K25-K27] | Discontinued in Phase 2 | [1] | ||
| Company |
Ikeda Mohando Co Ltd
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| Structure |
|
Download2D MOL |
|||
| Formula |
C22H32Cl2N4O2
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| Canonical SMILES |
n1c(=O)c(c([nH]c1NC/C=C\COc1cc(CN2CCCCC2)ccc1)C)C.Cl.Cl
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| CAS Number |
CAS 126868-88-0
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Histamine H2 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gastric acid secretion | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Histamine H2 receptor mediated signaling pathway | |||||
| PathWhiz Pathway | Intracellular Signalling Through Histamine H2 Receptor and Histamine | ||||
| Gastric Acid Production | |||||
| Reactome | Histamine receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Secretion of Hydrochloric Acid in Parietal Cells | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001447) | ||||
| REF 2 | Effects of IGN-2098, a new histamine H2-receptor antagonist, on gastric secretion and gastric and duodenal lesions induced in rats. Comparison with roxatidine. Nihon Yakurigaku Zasshi. 1992 Mar;99(3):167-80. | ||||
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