Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0D2MS
|
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| Former ID |
DNC008408
|
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| Drug Name |
5-methylenearisteromycin
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C12H15N5O3
|
||||
| Canonical SMILES |
C=C1C(C(C(C1N2C=NC3=C2N=CN=C3N)O)O)CO
|
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| InChI |
1S/C12H15N5O3/c1-5-6(2-18)9(19)10(20)8(5)17-4-16-7-11(13)14-3-15-12(7)17/h3-4,6,8-10,18-20H,1-2H2,(H2,13,14,15)/t6-,8+,9+,10-/m0/s1
|
||||
| InChIKey |
REGXGANNNMTWAW-ZQNVIIHSSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Adenosylhomocysteinase | Target Info | Inhibitor | [1] | |
| BioCyc Pathway | Superpathway of methionine degradation | ||||
| Methionine degradation | |||||
| Cysteine biosynthesis | |||||
| KEGG Pathway | Cysteine and methionine metabolism | ||||
| Metabolic pathways | |||||
| PathWhiz Pathway | Selenoamino Acid Metabolism | ||||
| Betaine Metabolism | |||||
| Methionine Metabolism | |||||
| WikiPathways | Metabolism of amino acids and derivatives | ||||
| Trans-sulfuration and one carbon metabolism | |||||
| One Carbon Metabolism | |||||
| Trans-sulfuration pathway | |||||
| Phase II conjugation | |||||
| Folate Metabolism | |||||
| References | |||||
| REF 1 | Bioorg Med Chem. 2008 Apr 1;16(7):3809-15. Epub 2008 Jan 30.Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase. | ||||
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