Drug Information

Drug General Information
Drug ID
D0D2XH
Former ID
DNC006693
Drug Name
4-(4-methoxy-1H-indol-1-ylsulfonyl)benzenamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528206]
Structure
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2D MOL

3D MOL
Formula
C15H14N2O3S
Canonical SMILES
COC1=CC=CC2=C1C=CN2S(=O)(=O)C3=CC=C(C=C3)N
InChI
1S/C15H14N2O3S/c1-20-15-4-2-3-14-13(15)9-10-17(14)21(18,19)12-7-5-11(16)6-8-12/h2-10H,16H2,1H3
InChIKey
ITHFAYACRWTMMR-UHFFFAOYSA-N
PubChem Compound ID
44413494
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [528206]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 528206Bioorg Med Chem Lett. 2006 Jul 15;16(14):3793-6. Epub 2006 May 18.Binding of methoxy-substituted N1-benzenesulfonylindole analogs at human 5-HT6 serotonin receptors.
Ref 528206Bioorg Med Chem Lett. 2006 Jul 15;16(14):3793-6. Epub 2006 May 18.Binding of methoxy-substituted N1-benzenesulfonylindole analogs at human 5-HT6 serotonin receptors.

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