Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0D3PZ
|
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| Former ID |
DIB019758
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| Drug Name |
dipropyl-5-CT
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| Synonyms |
DP-5-CT; DP5CT; N,N-dipropylcarboxamidotryptamine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C17H25N3O
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| InChI |
InChI=1S/C17H25N3O/c1-3-8-20(9-4-2)10-7-14-12-19-16-6-5-13(17(18)21)11-15(14)16/h5-6,11-12,19H,3-4,7-10H2,1-2H3,(H2,18,21)
|
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| InChIKey |
DPXOFRGRKPFZOD-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
10252872, 11111033, 15467773, 26755673, 46232141, 47350433, 47425374, 47574448, 47574449, 47796120, 48020066, 48095614, 50111034, 51017598, 57348262, 85209642, 85787317, 90340592, 104443505, 124749691, 124879818, 124879819, 127770003, 131342363, 134223554, 135112296, 135650195, 179235777, 234353577, 242145455
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| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 1B receptor | Target Info | Agonist | [2] | |
| 5-hydroxytryptamine 1F receptor | Target Info | Agonist | [3] | ||
| 5-hydroxytryptamine 1D receptor | Target Info | Agonist | [2] | ||
| 5-hydroxytryptamine 7 receptor | Target Info | Agonist | [4] | ||
| KEGG Pathway | cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapsehsa04024:cAMP signaling pathway | |||||
| Serotonergic synapsehsa04014:Ras signaling pathway | |||||
| Calcium signaling pathway | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| 5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| PathWhiz Pathway | Excitatory Neural Signalling Through 5-HTR 7 and Serotonin | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors | |||||
| G alpha (s) signalling events | |||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway | |||||
| GPCR downstream signaling | |||||
| GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway | |||||
| GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 122). | ||||
| REF 2 | Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3630-4. | ||||
| REF 3 | Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):408-12. | ||||
| REF 4 | Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b). Br J Pharmacol. 1997 Sep;122(1):126-32. | ||||
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