Drug General Information
Drug ID	D0D5HM
Former ID	DNC012723
Drug Name	4-Bromo-5,7-dichloro-3-hydroxy-1H-quinolin-2-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[551312]
Structure		Download 2D MOL 3D MOL
Formula	C9H4BrCl2NO2
Canonical SMILES	C1=C(C=C2C(=C1Cl)C(=C(C(=O)N2)O)Br)Cl
InChI	1S/C9H4BrCl2NO2/c10-7-6-4(12)1-3(11)2-5(6)13-9(15)8(7)14/h1-2,14H,(H,13,15)
InChIKey	HDPAPMXBVVKNAQ-UHFFFAOYSA-N
PubChem Compound ID	44364764
Target and Pathway
Target(s)	Glutamate [NMDA] receptor subunit epsilon 2	Target Info	Inhibitor	[551312]
	Glutamate [NMDA] receptor subunit epsilon 1	Target Info	Inhibitor	[551312]
	NMDA receptor subunit NR1	Target Info	Inhibitor	[551312]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Circadian entrainment
	Long-term potentiation
	Glutamatergic synapse
	Dopaminergic synapse
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)
	Huntington's disease
	Cocaine addiction
	Amphetamine addiction
	Nicotine addiction
	Alcoholism
	Systemic lupus erythematosushsa04014:Ras signaling pathway
	Calcium signaling pathway
PANTHER Pathway	Huntington disease
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database	ErbB4 signaling events
	Reelin signaling pathwayreelinpathway:Reelin signaling pathway
Reactome	EPHB-mediated forward signaling
	Unblocking of NMDA receptor, glutamate binding and activation
	CREB phosphorylation through the activation of CaMKII
	Ras activation uopn Ca2+ infux through NMDA receptor
	RAF/MAP kinase cascadeR-HSA-438066:Unblocking of NMDA receptor, glutamate binding and activation
	RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
	RAF/MAP kinase cascade
WikiPathways	Hypothetical Network for Drug Addiction
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	BDNF signaling pathwayWP666:Hypothetical Network for Drug Addiction
	Alzheimers DiseaseWP706:SIDS Susceptibility Pathways
	Spinal Cord Injury
	BDNF signaling pathway
	Alzheimers Disease
References
Ref 551312	3-Hydroxy-quinolin-2-ones: Inhibitors of [3H]-glycine binding to the site associated with the NMDA receptor, Bioorg. Med. Chem. Lett. 6(5):499-504 (1996).
Ref 551312	3-Hydroxy-quinolin-2-ones: Inhibitors of [3H]-glycine binding to the site associated with the NMDA receptor, Bioorg. Med. Chem. Lett. 6(5):499-504 (1996).

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