Drug Information

Drug General Information
Drug ID
D0D5VJ
Former ID
DIB008968
Drug Name
UK-432097
Synonyms
Adenosine A2a agonist (asthma), Pfizer
Drug Type
Small molecular drug
Indication Asthma; Chronic obstructive pulmonary disease [ICD9: 490-492, 493, 494-496; ICD10:J40-J44, J47, J45] Phase 2 [521962], [543123]
Company
Pfizer Inc
Structure
Download
2D MOL

3D MOL
Formula
C40H47N11O6
InChI
InChI=1S/C40H47N11O6/c1-2-41-37(54)33-31(52)32(53)39(57-33)51-24-46-30-34(45-23-28(25-11-5-3-6-12-25)26-13-7-4-8-14-26)48-35(49-36(30)51)38(55)43-19-20-44-40(56)47-27-16-21-50(22-17-27)29-15-9-10-18-42-29/h3-15,18,24,27-28,31-33,39,52-53H,2,16-17,19-23H2,1H3,(H,41,54)(H,43,55)(H2,44,47,56)(H,45,48,49)/t31-,32+,33-,39+/m0/s1
InChIKey
ZOTHAEBAWXWVID-HXEFRTELSA-N
PubChem Compound ID
9833519
PubChem Substance ID
14938124, 15138308, 24133294, 44931625, 77628380, 103749767, 104150573, 111978670, 143167583, 162224361, 170483814, 172113484, 198983573, 223864568, 227014598, 247977635, 252166630
Target and Pathway
Target(s) Adenosine A2a receptor Target Info Agonist [531387]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Parkinson's disease
Alcoholism
Pathway Interaction Database HIF-2-alpha transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome NGF-independant TRKA activation
Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
Monoamine Transport
GPCRs, Class A Rhodopsin-like
NGF signalling via TRKA from the plasma membrane
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 521962ClinicalTrials.gov (NCT00430300) Safety And Efficacy Of UK-432,097 In Chronic Obstructive Pulmonary Disease.. U.S. National Institutes of Health.
Ref 543123(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8420).
Ref 531387Structure of an agonist-bound human A2A adenosine receptor. Science. 2011 Apr 15;332(6027):322-7.

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