Drug General Information
Drug ID	D0D7XW
Former ID	DIB000927
Drug Name	SINITRODIL
Synonyms	ITF-296; Sinitrodil < Prop INN >; 3-[2-(Nitrooxy)ethyl]-2H-1,3-benzoxazin-4(3H)-one
Drug Type	Small molecular drug
Indication	Angina pectoris [ICD9: 413; ICD10:I20]		Discontinued in Phase 2	[545952]
Structure		Download 2D MOL 3D MOL
Formula	C10H10N2O5
Canonical SMILES	[O-][N+](=O)OCCN1COc2ccccc2C1=O
InChI	1S/C10H10N2O5/c13-10-8-3-1-2-4-9(8)16-7-11(10)5-6-17-12(14)15/h1-4H,5-7H2
InChIKey	POVFCWQCRHXYAB-UHFFFAOYSA-N
CAS Number	CAS 143248-63-9
PubChem Compound ID	121985
Target and Pathway
Target(s)	CGMP-specific 3',5'-cyclic phosphodiesterase	Target Info	Modulator	[551871]
KEGG Pathway	Purine metabolism
	cGMP-PKG signaling pathway
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
Reactome	cGMP effects
References
Ref 545952	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005482)
Ref 551871	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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