Drug Information

Drug General Information
Drug ID
D0D8CV
Former ID
DIB018345
Drug Name
[3H]MRE 3008F20
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468006]
Structure
Download
2D MOL
Formula
C21H20N8O3
InChI
InChI=1S/C21H20N8O3/c1-3-10-28-12-15-17(26-28)24-20(25-21(30)22-13-6-8-14(31-2)9-7-13)29-19(15)23-18(27-29)16-5-4-11-32-16/h4-9,11-12H,3,10H2,1-2H3,(H2,22,24,25,26,30)
InChIKey
CJRNHKSLHHWUAB-UHFFFAOYSA-N
PubChem Compound ID
5310960
PubChem Substance ID
7978524, 11056170, 14856642, 39340701, 52972179, 85209183, 103258962, 103982209, 127635111, 135650631, 135651181, 136351718, 143101689, 196376179, 202535714, 227218312, 241376777, 249618060, 252157734
Target and Pathway
Target(s) Adenosine A3 receptor Target Info Antagonist [525709]
Reactome Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCRs, Other
References
Ref 468006(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 477).
Ref 525709Synthesis and preliminary biological evaluation of [3H]-MRE 3008-F20: the first high affinity radioligand antagonist for the human A3 adenosine receptors. Bioorg Med Chem Lett. 2000 Feb 7;10(3):209-11.

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