Drug General Information
Drug ID	D0D9AD
Former ID	DIB013343
Drug Name	YM-750
Synonyms	ACAT inhibitors, Yamanouchi
Drug Type	Small molecular drug
Indication	Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78]		Discontinued in Phase 1	[545390]
Company	Yamanouchi Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C31H36N2O
Canonical SMILES	C(=O)(Nc1c(cc(cc1C)C)C)N(Cc1cc2c(c3c(C2)cccc3)cc1)C1CCC<br />CCC1
CAS Number	CAS 138046-43-2
PubChem Compound ID	9911716
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Inhibitor	[529169]
KEGG Pathway	Drug metabolism - other enzymes
	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 545390	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003090)
Ref 529169	Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell-derived foam cells. Life Sci. 2008 Jan 2;82(1-2):79-84. Epub 2007 Nov 26.

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