Drug Information

Drug General Information
Drug ID
D0DE8K
Former ID
DIB020208
Drug Name
lergotrile
Synonyms
LY 79907
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539760]
Structure
Download
2D MOL
Formula
C17H18ClN3
InChI
InChI=1S/C17H18ClN3/c1-21-9-10(5-6-19)7-12-11-3-2-4-14-16(11)13(8-15(12)21)17(18)20-14/h2-4,10,12,15,20H,5,7-9H2,1H3/t10-,12-,15-/m1/s1
InChIKey
JKAHWGPTNVUTNB-IXPVHAAZSA-N
PubChem Compound ID
6918447
PubChem Substance ID
12015262, 15443826, 17194895, 43529817, 47206526, 53749435, 57371934, 103280717, 134224043, 135650513, 137263741, 198987336, 226935088, 241066188
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Agonist [533689]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 539760(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 270).
Ref 533689Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol. 1993 Mar;43(3):320-7.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.