Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0DP6L
|
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| Former ID |
DAP001033
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| Drug Name |
Isoflurane
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| Synonyms |
Aerrane; Forane; Forene; IsoFlo; Isoflurano; Isofluranum; AErrane (Veterinary); Forane (TN); Isoflurane [Anaesthetics, volatile]; Isoflurano [INN-Spanish]; Isofluranum [INN-Latin]; R-E 235dal; Isoflurane (JP15/USP/INN); Isoflurane [USAN:BAN:INN:JAN]; Isoflurane [USAN:INN:BAN:JAN]; Ether, 1-chloro-2,2,2-trifluoroethyl difluoromethyl; 1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether; 2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane; 2-chloro-2-difluoromethoxy-1,1,1-trifluoroethane
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| Drug Type |
Small molecular drug
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| Therapeutic Class |
Anesthetics
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| Structure |
|
Download2D MOL |
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| Formula |
C3H2ClF5O
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| InChI |
InChI=1S/C3H2ClF5O/c4-1(3(7,8)9)10-2(5)6/h1-2H
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| InChIKey |
PIWKPBJCKXDKJR-UHFFFAOYSA-N
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| CAS Number |
CAS 26675-46-7
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| PubChem Compound ID | |||||
| PubChem Substance ID |
9721, 3159889, 3723212, 4697021, 7847611, 7979654, 8152381, 10516331, 15195236, 29222882, 46505880, 48413913, 49836645, 49857441, 50125772, 53790766, 53801075, 56310699, 56310955, 56311499, 56311786, 56311841, 56311862, 56313386, 56313446, 56313448, 56313544, 56313545, 57321983, 80689362, 85175968, 92714281, 97857709, 103385005, 104304448, 117648535, 118838432, 124893641, 125307939, 125346539, 126629601, 127261761, 127261762, 127261763, 127261764, 127261765, 127261766, 128922443, 131308078, 131465775
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| ChEBI ID |
ChEBI:6015
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| SuperDrug ATC ID |
N01AB06
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| SuperDrug CAS ID |
cas=026675467
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| Target and Pathway | |||||
| Target(s) | Glutamate receptor AMPA subtype | Target Info | Agonist | [535407], [536041] | |
| References | |||||
| Ref 536300 | Anaesthetic drugs: linking molecular actions to clinical effects. Curr Pharm Des. 2006;12(28):3665-79. | ||||
| Ref 539627 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2505). | ||||
| Ref 535407 | Effects of GABAergic agents on anesthesia induced by halothane, isoflurane, and thiamylal in mice. Pharmacol Biochem Behav. 2002 May;72(1-2):111-6. | ||||
| Ref 536041 | Transmembrane residues define the action of isoflurane at the GABAA receptor alpha-3 subunit. Brain Res. 2005 Jan 25;1032(1-2):30-5. | ||||
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