| Drug General Information |
| Drug ID |
D0DR8N
|
| Former ID |
DNC004083
|
| Drug Name |
AZAKENPAULLONE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C15H10BrN3O
|
| InChI |
InChI=1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)
|
| InChIKey |
NTSBZVCEIVPKBJ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
11108285, 11644850, 15372145, 26758278, 43184116, 51054469, 56311921, 57370924, 58713088, 91610624, 99302632, 103368597, 103905441, 134341288, 141575106, 162248452, 163125287, 163688554, 164836020, 177218158, 180386960, 184024335, 184525734, 184525755, 184525776, 184533108, 204424124, 226710153, 241126228, 247082686, 249565698, 252261743, 252469926
|
| Target and Pathway |
| Target(s) |
Glycogen synthase kinase-3 beta |
Target Info |
Inhibitor |
[2]
|
|---|
| Cell division control protein 2 homolog |
Target Info |
Inhibitor |
[2]
|
| Cell division protein kinase 5 |
Target Info |
Inhibitor |
[2]
|
| G2/mitotic-specific cyclin B1 |
Target Info |
Inhibitor |
[2]
|
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KEGG Pathway
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ErbB signaling pathway
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Chemokine signaling pathway
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Cell cycle
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|
PI3K-Akt signaling pathway
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Wnt signaling pathway
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Hedgehog signaling pathway
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Axon guidance
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Hippo signaling pathway
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Focal adhesion
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Signaling pathways regulating pluripotency of stem cells
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T cell receptor signaling pathway
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B cell receptor signaling pathway
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Neurotrophin signaling pathway
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Dopaminergic synapse
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Insulin signaling pathway
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Melanogenesis
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Prolactin signaling pathway
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Thyroid hormone signaling pathway
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Non-alcoholic fatty liver disease (NAFLD)
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Alzheimer's disease
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Hepatitis C
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Measles
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Influenza A
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HTLV-I infection
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Epstein-Barr virus infection
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Pathways in cancer
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Colorectal cancer
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Endometrial cancer
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Prostate cancer
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Basal cell carcinomahsa04110:Cell cycle
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Oocyte meiosis
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p53 signaling pathway
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Gap junction
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Progesterone-mediated oocyte maturation
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Herpes simplex infection
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Viral carcinogenesishsa04360:Axon guidance
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Cocaine addictionhsa04068:FoxO signaling pathway
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|
NetPath Pathway
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RANKL Signaling PathwayNetPath_4:EGFR1 Signaling Pathway
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TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
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PANTHER Pathway
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Alzheimer disease-presenilin pathway
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Angiogenesis
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Cadherin signaling pathway
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Hedgehog signaling pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Insulin/IGF pathway-protein kinase B signaling cascade
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Interleukin signaling pathway
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PDGF signaling pathway
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PI3 kinase pathway
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Wnt signaling pathway
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Ras Pathway
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CCKR signaling map STP00007:Axon guidance mediated by semaphorinsP00059:p53 pathway
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Pathway Interaction Database
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LPA receptor mediated events
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Degradation of beta catenin
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Reelin signaling pathway
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Presenilin action in Notch and Wnt signaling
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Integrin-linked kinase signaling
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CDC42 signaling events
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LKB1 signaling events
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Canonical Wnt signaling pathway
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Glucocorticoid receptor regulatory network
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C-MYC pathway
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Regulation of Androgen receptor activity
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BMP receptor signaling
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Hedgehog signaling events mediated by Gli proteins
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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Validated transcriptional targets of deltaNp63 isoforms
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Aurora A signaling
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Insulin-mediated glucose transport
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Class I PI3K signaling events mediated by Akt
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p53 pathway
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Trk receptor signaling mediated by PI3K and PLC-gammap73pathway:p73 transcription factor network
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E2F transcription factor network
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PLK1 signaling events
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AP-1 transcription factor network
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FOXM1 transcription factor network
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Retinoic acid receptors-mediated signalingreelinpathway:Reelin signaling pathway
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Lissencephaly gene (LIS1) in neuronal migration and development
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EPHA forward signaling
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Trk receptor signaling mediated by the MAPK pathwayp73pathway:p73 transcription factor network
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Validated targets of C-MYC transcriptional activation
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FoxO family signaling
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Direct p53 effectors
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C-MYB transcription factor network
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Reactome
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Degradation of beta-catenin by the destruction complex
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AKT phosphorylates targets in the cytosol
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Regulation of HSF1-mediated heat shock response
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CRMPs in Sema3A signaling
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Disassembly of the destruction complex and recruitment of AXIN to the membrane
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S33 mutants of beta-catenin aren't phosphorylated
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S37 mutants of beta-catenin aren't phosphorylated
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S45 mutants of beta-catenin aren't phosphorylated
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T41 mutants of beta-catenin aren't phosphorylated
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Degradation of GLI2 by the proteasome
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Constitutive Signaling by AKT1 E17K in CancerR-HSA-110056:MAPK3 (ERK1) activation
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E2F mediated regulation of DNA replication
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G0 and Early G1
|
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Cyclin B2 mediated events
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Golgi Cisternae Pericentriolar Stack Reorganization
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Cdc20:Phospho-APC/C mediated degradation of Cyclin A
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Regulation of APC/C activators between G1/S and early anaphase
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Phosphorylation of the APC/C
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Phosphorylation of Emi1
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Condensation of Prophase Chromosomes
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MASTL Facilitates Mitotic Progression
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Resolution of Sister Chromatid Cohesion
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Condensation of Prometaphase Chromosomes
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Regulation of PLK1 Activity at G2/M Transition
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Activation of NIMA Kinases NEK9, NEK6, NEK7
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Loss of Nlp from mitotic centrosomes
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Recruitment of mitotic centrosome proteins and complexes
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Loss of proteins required for interphase microtubule organization?from the centrosome
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Recruitment of NuMA to mitotic centrosomes
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Depolymerisation of the Nuclear Lamina
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Anchoring of the basal body to the plasma membrane
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MAPK6/MAPK4 signaling
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G1/S-Specific Transcription
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Cyclin A/B1 associated events during G2/M transition
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G2/M DNA replication checkpoint
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Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-180024:DARPP-32 events
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Factors involved in megakaryocyte development and platelet productionR-HSA-156711:Polo-like kinase mediated events
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Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
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WikiPathways
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DNA Damage Response (only ATM dependent)
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Senescence and Autophagy in Cancer
|
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Notch Signaling Pathway
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Glycogen Metabolism
|
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Insulin Signaling
|
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Wnt Signaling Pathway
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Wnt Signaling Pathway and Pluripotency
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IL-6 signaling pathway
|
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Wnt Signaling Pathway Netpath
|
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Copper homeostasis
|
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Focal Adhesion
|
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Hair Follicle Development: Induction (Part 1 of 3)
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Cardiac Hypertrophic Response
|
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Degradation of beta-catenin by the destruction complex
|
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T-Cell Receptor and Co-stimulatory Signaling
|
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Cardiac Progenitor Differentiation
|
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BDNF signaling pathway
|
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Corticotropin-releasing hormone
|
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B Cell Receptor Signaling Pathway
|
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IL17 signaling pathway
|
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Neural Crest Differentiation
|
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Alzheimers Disease
|
|
IL-7 Signaling Pathway
|
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Regulation of Microtubule Cytoskeleton
|
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TWEAK Signaling Pathway
|
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Leptin signaling pathway
|
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Semaphorin interactions
|
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Cell Cycle
|
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MicroRNAs in cardiomyocyte hypertrophy
|
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Androgen receptor signaling pathway
|
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IL-5 Signaling PathwayWP707:DNA Damage Response
|
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G1 to S cell cycle control
|
|
TGF beta Signaling Pathway
|
|
PPAR Alpha Pathway
|
|
MAP kinase activation in TLR cascade
|
|
RAF/MAP kinase cascade
|
|
Mitotic Prophase
|
|
Mitotic Prometaphase
|
|
BMI1
|
|
ATM Signaling Pathway
|
|
Retinoblastoma (RB) in Cancer
|
|
Spinal Cord Injury
|
|
Prostate Cancer
|
|
Integrated Cancer pathway
|
|
Mitotic G2-G2/M phases
|
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Mitotic G1-G1/S phases
|
|
APC/C-mediated degradation of cell cycle proteins
|
|
Cell Cycle Checkpoints
|
|
miRNA Regulation of DNA Damage ResponseWP707:DNA Damage Response
|
|
Opioid Signalling
|
|
Factors involved in megakaryocyte development and platelet production
|
|
Nicotine Activity on Dopaminergic Neurons
|
|
miRNA Regulation of DNA Damage Response
|
|
AMPK Signaling
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8018). |
|---|
| REF 2 | Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6.1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. |
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