Drug Information

Drug General Information
Drug ID
D0E0KQ
Former ID
DAP001508
Drug Name
Pyronaridine
Synonyms
Malaridine; Pyronaridine phosphate salt; Benzonaphthyridine 7351; 2-Methoxy-7-chloro-10-(3',5'-bis(pyrrolin-1-ylmethyl)-4'-hydroxyphenylamino)benzo(b)-1,5-naphthyridine; 4-((7-Chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pyrrolidinylmethyl)phenol; 4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one; 4-[(7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(pyrrolidin-1-ylmethyl)phenol
Drug Type
Small molecular drug
Indication Malaria [ICD10:B54] Approved [551871]
Structure
Download
2D MOL

3D MOL
Formula
C29H32ClN5O2
Canonical SMILES
COC1=CC=C2C(=C(C3=C(N2)C=C(C=C3)Cl)N=C4C=C(C(=O)C(=C4)C<br />N5CCCC5)CN6CCCC6)N1
InChI
1S/C29H32ClN5O2/c1-37-26-9-8-24-28(33-26)27(23-7-6-21(30)16-25(23)32-24)31-22-14-19(17-34-10-2-3-11-34)29(36)20(15-22)18-35-12-4-5-13-35/h6-9,14-16,32-33H,2-5,10-13,17-18H2,1H3
InChIKey
YFYLPWJKCSESGB-UHFFFAOYSA-N
CAS Number
CAS 74847-35-1
PubChem Compound ID
5485198
PubChem Substance ID
14836281, 37375204, 39472434, 50065153, 57364048, 76896800, 90452320, 93625661, 103210597, 113993147, 117793601, 124952509, 125325465, 131801476, 134338695, 135066549, 135959505, 137006529, 144233411, 163667393, 166240084, 174006948, 175265429, 179148054, 198992732, 223705403, 223718772, 226596943, 227839360, 241134503, 251912260, 251916561, 252633485
Target and Pathway
Target(s) Sarcoplasmic/endoplasmic reticulum calcium ATPase Target Info Inhibitor [536602]
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536602The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.

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