Drug General Information
Drug ID	D0E1UZ
Former ID	DIB011686
Drug Name	CL-283796
Synonyms	ACB-796; N-(4-Chloro-2,6-dimethylphenyl)-N'-heptyl-N'-[4-(3-methylbutyl)benzyl]urea
Indication	Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78]		Discontinued in Phase 2	[545762]
Structure		Download 2D MOL 3D MOL
CAS Number	CAS 107376-72-7
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Modulator	[531635], [533685]
KEGG Pathway	Drug metabolism - other enzymes
	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 545762	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004604)
Ref 531635	Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.
Ref 533685	ACAT inhibitors CL 283,546 and CL 283,796 reduce LDL cholesterol without affecting cholesterol absorption in African green monkeys. J Lipid Res. 1995 Jun;36(6):1199-210.

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