Drug Information

Drug General Information
Drug ID
D0E2WX
Former ID
DNC000083
Drug Name
5-Fluoro orotate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535811]
Structure
Download
2D MOL

3D MOL
Formula
C5H3FN2O4
Canonical SMILES
C1(=C(NC(=O)NC1=O)C(=O)O)F
InChI
1S/C5H3FN2O4/c6-1-2(4(10)11)7-5(12)8-3(1)9/h(H,10,11)(H2,7,8,9,12)
InChIKey
SEHFUALWMUWDKS-UHFFFAOYSA-N
PubChem Compound ID
69711
PubChem Substance ID
90504, 3153098, 5475000, 5649795, 8193186, 15120499, 15237848, 24423710, 26665898, 29200902, 43126167, 49747497, 50035842, 57317513, 79239090, 85086136, 85245872, 87570153, 91613269, 103145057, 104248978, 104345707, 117542376, 118314454, 124441995, 124953268, 125130898, 125356484, 126632763, 126658991, 126690013, 127324882, 127324883, 129223725, 134339616, 135026731, 136992188, 137023646, 143438861, 143551517, 144223859, 160813742, 162092756, 162178809, 163089708, 163373396, 164849284, 165235677, 165246065, 171580051
SuperDrug ATC ID
L01BC02
SuperDrug CAS ID
cas=000051218
Target and Pathway
Target(s) Dihydroorotase Target Info Inhibitor [535811]
Dihydroorotate dehydrogenase, mitochondrial Target Info Inhibitor [535811]
KEGG Pathway Pyrimidine metabolism
Metabolic pathways
PathWhiz Pathway Pyrimidine Metabolism
Reactome Pyrimidine biosynthesis
WikiPathways Metabolism of nucleotides
References
Ref 535811Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301.
Ref 535811Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301.

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