Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0E3FR
|
||||
| Former ID |
DIB020372
|
||||
| Drug Name |
ML297
|
||||
| Synonyms |
ML-297; ML 297
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C17H14F2N4O
|
||||
| InChI |
InChI=1S/C17H14F2N4O/c1-11-9-16(23(22-11)13-5-3-2-4-6-13)21-17(24)20-12-7-8-14(18)15(19)10-12/h2-10H,1H3,(H2,20,21,24)
|
||||
| InChIKey |
IEKSMUSSYJUQMY-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Potassium channel KCNJ3 Kir3.1 | Target Info | Activator | [2] | |
| KEGG Pathway | Circadian entrainment | ||||
| Retrograde endocannabinoid signaling | |||||
| Glutamatergic synapse | |||||
| Cholinergic synapse | |||||
| Serotonergic synapse | |||||
| Dopaminergic synapse | |||||
| Estrogen signaling pathway | |||||
| Oxytocin signaling pathway | |||||
| Morphine addiction | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | |||||
| GABA-B receptor II signaling | |||||
| PathWhiz Pathway | Muscle/Heart Contraction | ||||
| Reactome | Activation of G protein gated Potassium channels | ||||
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | |||||
| WikiPathways | Calcium Regulation in the Cardiac Cell | ||||
| G Protein Signaling Pathways | |||||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| Potassium Channels | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7768). | ||||
| REF 2 | ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS Chem Neurosci. 2013 Sep 18;4(9):1278-86. | ||||
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