Drug Information

Drug General Information
Drug ID
D0E3GI
Former ID
DIB019007
Drug Name
BPH-629
Synonyms
BPH 629; BPH629
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542892]
Structure
Download
2D MOL
Formula
C20H18O8P2
InChI
InChI=1S/C20H18O8P2/c21-20(29(22,23)24,30(25,26)27)12-13-5-3-6-14(11-13)15-8-4-9-17-16-7-1-2-10-18(16)28-19(15)17/h1-11,21H,12H2,(H2,22,23,24)(H2,25,26,27)
InChIKey
BYVXAUZOTGITQZ-UHFFFAOYSA-N
PubChem Compound ID
16122553
PubChem Substance ID
24770088, 24770093, 40656489, 56374429, 56479596, 99443881, 103567707, 127341701, 127341702, 137244839, 160968490, 172659346, 172659347, 249565659
Target and Pathway
Target(s) Geranyltranstransferase Target Info Inhibitor [528871]
BioCyc Pathway Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Superpathway of cholesterol biosynthesis
Trans, trans-farnesyl diphosphate biosynthesis
Geranylgeranyldiphosphate biosynthesis
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
PANTHER Pathway Cholesterol biosynthesis
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
WikiPathways Activation of Gene Expression by SREBP (SREBF)
References
Ref 542892(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7976).
Ref 528871Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10022-7. Epub 2007 May 29.

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