Drug General Information
Drug ID	D0E3IK
Former ID	DNC006210
Drug Name	N-(2-Propyloxy-4-nitrophenyl)methanesulfonamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528035]
Structure		Download 2D MOL 3D MOL
Formula	C10H14N2O5S
Canonical SMILES	CCCOC1=C(C=CC(=C1)[N+](=O)[O-])NS(=O)(=O)C
InChI	1S/C10H14N2O5S/c1-3-6-17-10-7-8(12(13)14)4-5-9(10)11-18(2,15)16/h4-5,7,11H,3,6H2,1-2H3
InChIKey	GUPXOWXEFMIHHE-UHFFFAOYSA-N
PubChem Compound ID	11680642
Target and Pathway
Target(s)	Cytochrome P450 19	Target Info	Inhibitor	[528035]
BioCyc Pathway	Superpathway of steroid hormone biosynthesis
	Estradiol biosynthesis II
	Estradiol biosynthesis I
KEGG Pathway	Steroid hormone biosynthesis
	Metabolic pathways
	Ovarian steroidogenesis
NetPath Pathway	FSH Signaling Pathway
PANTHER Pathway	Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway	Androgen and Estrogen Metabolism
Reactome	Endogenous sterols
WikiPathways	Metapathway biotransformation
	Tryptophan metabolism
	Oxidation by Cytochrome P450
	Ovarian Infertility Genes
	Metabolism of steroid hormones and vitamin D
	FSH signaling pathway
	Integrated Breast Cancer Pathway
	Phase 1 - Functionalization of compounds
References
Ref 528035	J Med Chem. 2006 Feb 23;49(4):1413-9.Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition.
Ref 528035	J Med Chem. 2006 Feb 23;49(4):1413-9.Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition.

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