Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0E4ON
|
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| Former ID |
DNC008169
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| Drug Name |
N-butyl-4-methyl-3,4-dihydroquinazolin-2-amine
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C13H19N3
|
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| Canonical SMILES |
CCCCNC1=NC(C2=CC=CC=C2N1)C
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| InChI |
1S/C13H19N3/c1-3-4-9-14-13-15-10(2)11-7-5-6-8-12(11)16-13/h5-8,10H,3-4,9H2,1-2H3,(H2,14,15,16)
|
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| InChIKey |
GRYGBTWCDTXWJO-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 5A receptor | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2008 Jan 1;18(1):262-6. Epub 2007 Oct 30.Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: optimising brain penetration. | ||||
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