Drug Information

Drug General Information
Drug ID
D0E7AZ
Former ID
DIB021059
Drug Name
tiotidine
Synonyms
ICI 125,211; ICI-125211
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538748]
Structure
Download
2D MOL
Formula
C10H16N8S2
InChI
InChI=1S/C10H16N8S2/c1-14-9(16-6-11)15-2-3-19-4-7-5-20-10(17-7)18-8(12)13/h5H,2-4H2,1H3,(H2,14,15,16)(H4,12,13,17,18)
InChIKey
YDDXVAXDYKBWDX-UHFFFAOYSA-N
PubChem Compound ID
50287
PubChem Substance ID
4746055, 11113722, 14850128, 22395698, 26756614, 34714865, 47207815, 47285824, 48029619, 49846382, 50065078, 50174732, 56464665, 57309564, 57313278, 85209333, 85788115, 91746436, 92308961, 103173478, 104294281, 124897822, 129778732, 135009327, 135651265, 135698100, 137262864, 140128370, 144205594, 162022584, 170466487, 176484000, 178100786, 179293855, 179339571, 180371818, 184548222, 198973299, 224814041, 226490403, 234749296, 241181916, 241377493, 249617212
Target and Pathway
Target(s) Histamine H2 receptor Target Info Antagonist [534519]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway Intracellular Signalling Through Histamine H2 Receptor and Histamine
Gastric Acid Production
Reactome Histamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 538748(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1235).
Ref 534519Heterologous expression of rat epitope-tagged histamine H2 receptors in insect Sf9 cells. Br J Pharmacol. 1997 Nov;122(5):867-74.

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