Drug Information

Drug General Information
Drug ID
D0E9AL
Former ID
DIB019006
Drug Name
BPH-628
Synonyms
BPH 628; B28; BPH628
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540166]
Structure
Download
2D MOL
Formula
C20H20O7P2
InChI
InChI=1S/C20H20O7P2/c21-20(28(22,23)24,29(25,26)27)14-15-5-4-8-19(13-15)18-11-9-17(10-12-18)16-6-2-1-3-7-16/h1-13,21H,14H2,(H2,22,23,24)(H2,25,26,27)
InChIKey
MPBUFKZCEBTBSK-UHFFFAOYSA-N
PubChem Compound ID
16122554
PubChem Substance ID
24770095, 40656490, 56374407, 99443880, 103567691, 127341699, 127341700, 135650016, 160968489
Target and Pathway
Target(s) Geranyltranstransferase Target Info Inhibitor [529700]
BioCyc Pathway Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Superpathway of cholesterol biosynthesis
Trans, trans-farnesyl diphosphate biosynthesis
Geranylgeranyldiphosphate biosynthesis
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
PANTHER Pathway Cholesterol biosynthesis
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
WikiPathways Activation of Gene Expression by SREBP (SREBF)
References
Ref 540166(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3188).
Ref 529700Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem. 2008 Sep 25;51(18):5594-607.

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