Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0EY2F
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| Former ID |
DNC011345
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| Drug Name |
7-hydroxy-6-propionyl-2H-chromen-2-one
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C12H10O4
|
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| Canonical SMILES |
CCC(=O)C1=C(C=C2C(=C1)C=CC(=O)O2)O
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| InChI |
1S/C12H10O4/c1-2-9(13)8-5-7-3-4-12(15)16-11(7)6-10(8)14/h3-6,14H,2H2,1H3
|
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| InChIKey |
GJOCMGDMAGUOKE-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Carbonic anhydrase IX | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Nitrogen metabolism | ||||
| Pathway Interaction Database | HIF-1-alpha transcription factor network | ||||
| Reactome | Regulation of gene expression by Hypoxia-inducible Factor | ||||
| Reversible hydration of carbon dioxide | |||||
| WikiPathways | Vitamin D Receptor Pathway | ||||
| Reversible Hydration of Carbon Dioxide | |||||
| Regulation of Hypoxia-inducible Factor (HIF) by Oxygen | |||||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. Epub 2010 Oct 25.7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range. | ||||
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