Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0F0JJ
|
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| Former ID |
DCL000107
|
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| Drug Name |
E2012
|
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| Drug Type |
Small molecular drug
|
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| Company |
Eisai
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C25H26FN3O2
|
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| InChI |
InChI=1S/C25H26FN3O2/c1-17-15-28(16-27-17)23-11-6-19(14-24(23)31-3)13-21-5-4-12-29(25(21)30)18(2)20-7-9-22(26)10-8-20/h6-11,13-16,18H,4-5,12H2,1-3H3/b21-13+/t18-/m0/s1
|
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| InChIKey |
PUOAETJYKQITMO-LANLRWRYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
16663032, 23680594, 42702678, 77115212, 104244932, 121279264, 126679802, 136968095, 140503079, 151991035, 152258061, 160646899, 162011922, 163392307, 163842696, 163887302, 172125920, 172918933, 174531119, 178103930, 185998796, 223683735, 224228882, 227468323, 227468327, 241156597, 249793847, 252479177
|
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| Target and Pathway | |||||
| Target(s) | Gamma-secretase | Target Info | Modulator | ||
| KEGG Pathway | Notch signaling pathway | ||||
| Alzheimer's disease | |||||
| Reactome | Nuclear signaling by ERBB4 | ||||
| Regulated proteolysis of p75NTR | |||||
| NRIF signals cell death from the nucleus | |||||
| Activated NOTCH1 Transmits Signal to the Nucleus | |||||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
| NOTCH2 Activation and Transmission of Signal to the Nucleus | |||||
| EPH-ephrin mediated repulsion of cells | |||||
| References | |||||
| Ref 542379 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7358). | ||||
| Ref 548575 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026719) | ||||
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