Drug General Information
Drug ID	D0F3FB
Former ID	DIB006072
Drug Name	S-9977
Synonyms	S-9977-2
Drug Type	Small molecular drug
Indication	Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3]		Discontinued in Phase 2	[544962]
Company	Servier
Structure		Download 2D MOL 3D MOL
Formula	C20H34ClN7O3
Canonical SMILES	c12c(c(=O)n(c(=O)n1C)C)n(c(n2)CCCN1CCN(C(=O)N(CC)CC)CC1<br />)C.Cl
CAS Number	CAS 138472-18-1
PubChem Compound ID	132156
Target and Pathway
Target(s)	Acetylcholinesterase	Target Info	Inhibitor	[526803]
KEGG Pathway	Glycerophospholipid metabolism
	Cholinergic synapse
PANTHER Pathway	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathway
	Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database	ATF-2 transcription factor network
PathWhiz Pathway	Phospholipid Biosynthesis
WikiPathways	Monoamine Transport
	Biogenic Amine Synthesis
	Acetylcholine Synthesis
	Integrated Pancreatic Cancer Pathway
References
Ref 544962	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001724)
Ref 526803	Xanthine derivatives IBMX and S-9977-2 potentiate transmission at an Aplysia central cholinergic synapse. Brain Res. 1992 Jul 17;586(1):78-85.

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