TTD | Drug: D0F7XM

Drug General Information
Drug ID	D0F7XM
Former ID	DIB018464
Drug Name	12-epi LTB4
Synonyms	12(S)-Leukotriene B4
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541351]
Structure		Download 2D MOL
Formula	C20H32O4
InChI	InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19+/m0/s1
InChIKey	VNYSSYRCGWBHLG-CBBLYLIKSA-N
PubChem Compound ID	5283130
PubChem Substance ID	4266081, 24583645, 39316544, 57358861, 79593897, 113859175, 126525356, 178102781, 179656335, 184568120, 223442607, 229170870, 242457107
Target and Pathway
Target(s)	Leukotriene B4 receptor 2	Target Info	Agonist	[526017]
KEGG Pathway	Calcium signaling pathway
KEGG Pathway	Neuroactive ligand-receptor interaction
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
Reactome	Leukotriene receptors
Reactome	G alpha (q) signalling events
WikiPathways	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 541351	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6160).
Ref 526017	Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J Biol Chem. 2001 Apr 13;276(15):12454-9. Epub 2001 Jan 18.

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Drug Information