| Drug General Information |
| Drug ID |
D0F8TG
|
| Former ID |
DIB019862
|
| Drug Name |
fluperlapine
|
| Synonyms |
C10967
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C19H20FN3
|
| InChI |
InChI=1S/C19H20FN3/c1-22-8-10-23(11-9-22)19-17-5-3-2-4-14(17)12-15-6-7-16(20)13-18(15)21-19/h2-7,13H,8-12H2,1H3
|
| InChIKey |
OBWGMKKHCLHVIE-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
13150, 6609373, 7979279, 8181097, 12013044, 16827998, 26719743, 26754614, 29216069, 34714146, 46386904, 47212922, 47359854, 47657071, 48105148, 49681763, 50065048, 51161839, 57313198, 85209079, 85787799, 92308651, 92309148, 103259587, 103972301, 104357644, 118047217, 124659076, 124892258, 126418611, 128786630, 134222176, 135009043, 135650274, 137213959, 144205333, 162022405, 162221781, 163134726, 164824850, 170466413, 172080466, 176484515, 179150902, 184596034, 198943533, 223439752, 226509411, 241118261, 250081671
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 7 receptor |
Target Info |
Antagonist |
[2]
|
|---|
| 5-hydroxytryptamine 6 receptor |
Target Info |
Antagonist |
[2]
|
|
KEGG Pathway
|
Ras signaling pathway
|
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Serotonergic synapsehsa04020:Calcium signaling pathway
|
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cAMP signaling pathway
|
|
Serotonergic synapse
|
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PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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PathWhiz Pathway
|
Excitatory Neural Signalling Through 5-HTR 7 and SerotoninPW000444:Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
|
|
Reactome
|
Serotonin receptors
|
|
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
|
|
G alpha (s) signalling events
|
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WikiPathways
|
Serotonin Receptor 4/6/7 and NR3C Signaling
|
|
Monoamine GPCRs
|
|
GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signaling
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GPCRs, OtherWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 279). |
|---|
| REF 2 | Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther. 1994 Mar;268(3):1403-10. |
|---|
