Drug Information

Drug General Information
Drug ID
D0F9NL
Former ID
DIB018471
Drug Name
12S-HPETE
Synonyms
12-(S)-hydroperoxyeicosatetraenoic acid; 12-(S)-HPETE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539606]
Structure
Download
2D MOL
Formula
C20H32O4
InChI
InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1
InChIKey
ZIOZYRSDNLNNNJ-LQWMCKPYSA-N
PubChem Compound ID
5280892
PubChem Substance ID
8249, 4266119, 8143293, 8616431, 14826969, 15249371, 26754759, 26754760, 39289881, 47364911, 47959452, 50076837, 50110771, 53800990, 57357916, 77144802, 92309737, 99300651, 99302169, 104046398, 113854188, 126525051, 137071982, 142970223, 164757246, 179205523, 227170720, 241130737, 242252371, 252371186, 252455461, 252463853
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Activator [525777]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 539606(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2481).
Ref 525777Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. Proc Natl Acad Sci U S A. 2000 May 23;97(11):6155-60.

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