Drug General Information
Drug ID	D0FX4J
Former ID	DIB014902
Drug Name	Telenzepine
Synonyms	BY-802
Drug Type	Small molecular drug
Indication	Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47]		Discontinued in Preregistration	[544690]
Company	ALTANA Pharma AG
Structure		Download 2D MOL 3D MOL
Formula	C19H22N4O2S
Canonical SMILES	n1(c2c(c(=O)[nH]c3c1cccc3)csc2C)C(=O)CN1CCN(CC1)C
CAS Number	CAS 80880-90-6
PubChem Compound ID	5387
Target and Pathway
Target(s)	Muscarinic acetylcholine receptor M1	Target Info	Modulator	[533879]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	PI3K-Akt signaling pathway
	Cholinergic synapse
	Regulation of actin cytoskeleton
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Reactome	Muscarinic acetylcholine receptors
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544690	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000603)
Ref 533879	Effect of telenzepine, an M1-selective muscarinic receptor antagonist, in patients with nocturnal asthma. Pulm Pharmacol. 1994 Apr;7(2):91-7.

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