TTD | Drug: D0G0HK

Drug General Information
Drug ID	D0G0HK
Former ID	DNC014894
Drug Name	GNF-PF-4453
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531262]
Structure		Download 2D MOL 3D MOL
Formula	C24H32N4O4
Canonical SMILES	CC1CC(CN(C1)CCCNC2=C(C=C(C=C2)C(=O)NC3=CC(=CC=C3)OC)[N+<br />](=O)[O-])C
InChI	1S/C24H32N4O4/c1-17-12-18(2)16-27(15-17)11-5-10-25-22-9-8-19(13-23(22)28(30)31)24(29)26-20-6-4-7-21(14-20)32-3/h4,6-9,13-14,17-18,25H,5,10-12,15-16H2,1-3H3,(H,26,29)
InChIKey	LRAMWMMVZIGQPU-UHFFFAOYSA-N
PubChem Compound ID	16194189
Target and Pathway
Target(s)	Calpain	Target Info	Inhibitor	[531262]
KEGG Pathway	Protein processing in endoplasmic reticulum
	Apoptosis
	Alzheimer's disease
Reactome	Degradation of the extracellular matrix
WikiPathways	Focal Adhesion
	Integrated Pancreatic Cancer Pathway
	Alzheimers Disease
	Integrin-mediated Cell Adhesion
References
Ref 531262	Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).
Ref 531262	Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).

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Drug Information