Drug Information

Drug General Information
Drug ID
D0G3MD
Former ID
DNC014062
Drug Name
(4-Quinolin-2-ylpiperazin-1-yl)acetic Acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530114]
Structure
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2D MOL

3D MOL
Formula
C15H17N3O2
Canonical SMILES
C1CN(CCN1CC(=O)O)C2=NC3=CC=CC=C3C=C2
InChI
1S/C15H17N3O2/c19-15(20)11-17-7-9-18(10-8-17)14-6-5-12-3-1-2-4-13(12)16-14/h1-6H,7-11H2,(H,19,20)
InChIKey
HCRXUFYSLPXCDW-UHFFFAOYSA-N
PubChem Compound ID
715494
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Inhibitor [530114]
5-hydroxytryptamine receptor 3A Target Info Inhibitor [530114]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04726:Serotonergic synapse
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP04375:5HT3 type receptor mediated signaling pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-975298:Ligand-gated ion channel transport
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic NeuronsWP706:SIDS Susceptibility Pathways
Iron uptake and transport
References
Ref 530114J Med Chem. 2009 Jun 11;52(11):3548-62.Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.
Ref 530114J Med Chem. 2009 Jun 11;52(11):3548-62.Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.

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