Drug Information

Drug General Information
Drug ID
D0G4CI
Former ID
DIB020342
Drug Name
methylglyoxal
Synonyms
pyruvaldehyde; acetylformaldehyde
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541453]
Structure
Download
2D MOL

3D MOL
Formula
C3H4O2
InChI
InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3
InChIKey
AIJULSRZWUXGPQ-UHFFFAOYSA-N
PubChem Compound ID
880
PubChem Substance ID
2945, 3827, 119143, 228444, 422484, 422485, 493005, 841795, 3137281, 5568782, 7890118, 8145726, 8150843, 10536063, 11528732, 15321021, 24439239, 24885071, 24896540, 24901425, 37336172, 46509036, 48414820, 50182604, 53790981, 56312073, 56313834, 56369729, 57288600, 57320562, 81044507, 85087720, 88811990, 92298545, 103429556, 104225911, 104296126, 104667741, 117359701, 117359702, 118980198, 124398000, 125374492, 126523848, 126678124, 127411153, 128506803, 128557784, 129252401, 134971237
Target and Pathway
Target(s) Transient receptor potential cation channel subfamily A member 1 Target Info Activator [531723]
KEGG Pathway Inflammatory mediator regulation of TRP channels
Reactome TRP channels
References
Ref 541453(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6303).
Ref 531723Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy. Pharmacol Res. 2012 Jan;65(1):149-58.

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