Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0G7SP
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| Former ID |
DIB005901
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| Drug Name |
SB-209247
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| Synonyms |
Ticolubant; LTB4 antagonist, SB
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| Drug Type |
Small molecular drug
|
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| Indication | Psoriasis [ICD9: 696; ICD10:L40] | Terminated | [1] | ||
| Company |
SmithKline Beecham plc
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| Structure |
|
Download2D MOL |
|||
| Formula |
C23H19Cl2NO3S
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| Canonical SMILES |
c1(SCc2nc(/C=C/C(=O)O)c(cc2)OCCc2ccccc2)c(Cl)cccc1Cl
|
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| CAS Number |
CAS 154413-61-3
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Leukotriene B4 receptor 1 | Target Info | Antagonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| Reactome | Leukotriene receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Nucleotide GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Spinal Cord Injury | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006734) | ||||
| REF 2 | Formation and protein binding of the acyl glucuronide of a leukotriene B4 antagonist (SB-209247): relation to species differences in hepatotoxicity. Drug Metab Dispos. 2005 Feb;33(2):271-81. Epub 2004 Nov 2. | ||||
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