Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0G8BN
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| Former ID |
DNC004663
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| Drug Name |
CAPSAZEPINE
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C19H21ClN2O2S
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| InChI |
InChI=1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)
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| InChIKey |
DRCMAZOSEIMCHM-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
3153122, 4689287, 7978851, 8794630, 11110887, 11113514, 11120274, 11120762, 11121250, 11121615, 11122095, 11362684, 11365246, 11367808, 11370639, 11370640, 11373409, 11375970, 14755701, 17404936, 24277967, 26751729, 26758380, 30091315, 47515104, 47810533, 48258992, 49688358, 49877927, 50104422, 50104423, 52479418, 53777479, 53790523, 56463490, 57409553, 71822557, 85084530, 85230948, 85788750, 90340779, 91611492, 92303760, 92309966, 99300878, 99302398, 103546395, 103904082, 111358572, 113635233
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| Target and Pathway | |||||
| Target(s) | Transient receptor potential cation channel subfamily V member 4 | Target Info | Inhibitor | [2] | |
| Vanilloid receptor 1 | Target Info | Inhibitor | [3] | ||
| Vanilloid receptor | Target Info | Inhibitor | [3] | ||
| KEGG Pathway | Inflammatory mediator regulation of TRP channelshsa04080:Neuroactive ligand-receptor interaction | ||||
| Inflammatory mediator regulation of TRP channels | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | ||||
| Trk receptor signaling mediated by PI3K and PLC-gamma | |||||
| Reactome | TRP channelsR-HSA-3295583:TRP channels | ||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2461). | ||||
| REF 2 | Bioorg Med Chem Lett. 2003 May 5;13(9):1549-52.Chain-branched acyclic phenethylthiocarbamates as vanilloid receptor antagonists. | ||||
| REF 3 | J Med Chem. 2007 May 31;50(11):2589-96. Epub 2007 May 10.The potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of pain. | ||||
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