Drug Information
Drug General Information | |||||
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Drug ID |
D0G8BV
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Former ID |
DAP001389
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Drug Name |
Guggulsterone
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Synonyms |
Guggulsterone E; Guggulsterones E; Guggulsterones Z; Cis-Guggulsterone; E-Guggulsteron; E-Guggulsterone; Trans-Guggulsterone; Z-Guggulsterone; Pregna-4,17-diene-3,16-dione; (17E)-Pregna-4,17(20)-diene-3,16-dione; (17E)-pregna-4,17-diene-3,16-dione; (17Z)-Pregna-4,17(20)-diene-3,16-dione; (17Z)-pregna-4,17-diene-3,16-dione; (8R,9S,10R,13S,14S,17E)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione; (8R,9S,10R,13S,14S,17Z)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione; (Z)-Guggulsterone; 4,17(20)-cis-Pregnadiene-3,16-dione
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Drug Type |
Small molecular drug
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Therapeutic Class |
Antiinflammatory Agents
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Structure |
Download2D MOL |
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Formula |
C21H28O2
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InChI |
InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4-/t15-,17+,18+,20+,21-/m1/s1
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InChIKey |
WDXRGPWQVHZTQJ-AUKWTSKRSA-N
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CAS Number |
CAS 95975-55-6
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PubChem Compound ID | |||||
PubChem Substance ID |
11968418, 12014199, 14776672, 16785310, 17388984, 43032812, 47290858, 48425176, 53786929, 57368784, 75135369, 103557435, 104097121, 114560011, 121277970, 124891536, 126662501, 134338597, 134345283, 135102533, 135232087, 135652690, 137267509, 137267510, 144207512, 152035987, 162175698, 162247924, 177749507, 179323901, 180100214, 198955980, 198979541, 223686210, 227839216, 241068353, 249617470, 252156260
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Target and Pathway | |||||
Target(s) | Bile acid receptor | Target Info | Antagonist | [536996] | |
KEGG Pathway | Bile secretion | ||||
Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | ||||
References | |||||
Ref 536258 | Treating insomnia: Current and investigational pharmacological approaches. Pharmacol Ther. 2006 Dec;112(3):612-29. Epub 2006 Jul 28. | ||||
Ref 539790 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2745). |
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