Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0H2KD
|
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| Former ID |
DNC005887
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| Drug Name |
(1H-indol-2-yl)(piperazin-1-yl)methanone
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C13H15N3O
|
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| Canonical SMILES |
C1CN(CCN1)C(=O)C2=CC3=CC=CC=C3N2
|
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| InChI |
1S/C13H15N3O/c17-13(16-7-5-14-6-8-16)12-9-10-3-1-2-4-11(10)15-12/h1-4,9,14-15H,5-8H2
|
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| InChIKey |
FIVCRRVYLAXYFC-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Histamine H4 receptor | Target Info | Inhibitor | [1] | |
| Histamine H3 receptor | Target Info | Inhibitor | [1] | ||
| KEGG Pathway | Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction | ||||
| Reactome | Histamine receptors | ||||
| G alpha (i) signalling eventsR-HSA-390650:Histamine receptors | |||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCR ligand binding | ||||
| GPCR downstream signaling | |||||
| GPCRs, OtherWP727:Monoamine Transport | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| References | |||||
| REF 1 | J Med Chem. 2005 Dec 29;48(26):8289-98.Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists. | ||||
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