TTD | Drug: D0H2VA

Drug General Information
Drug ID	D0H2VA
Former ID	DNC004678
Drug Name	LUF-5853
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529299]
Structure		Download 2D MOL 3D MOL
Formula	C16H12N4O3S
Canonical SMILES	C1OC2=C(O1)C=C(C=C2)C3=C(C(=NC(=C3C#N)SCCO)N)C#N
InChI	1S/C16H12N4O3S/c17-6-10-14(9-1-2-12-13(5-9)23-8-22-12)11(7-18)16(20-15(10)19)24-4-3-21/h1-2,5,21H,3-4,8H2,(H2,19,20)
InChIKey	KQKVGJJOJHCKQA-UHFFFAOYSA-N
PubChem Compound ID	9884349
Target and Pathway
Target(s)	Adenosine A1 receptor	Target Info	Inhibitor	[529299]
KEGG Pathway	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Sphingolipid signaling pathway
	Neuroactive ligand-receptor interaction
	Morphine addiction
NetPath Pathway	TCR Signaling Pathway
NetPath Pathway	RANKL Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome	Adenosine P1 receptors
Reactome	G alpha (i) signalling events
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 529299	Bioorg Med Chem. 2008 Mar 15;16(6):2741-52. Epub 2008 Jan 12.A new generation of adenosine receptor antagonists: from di- to trisubstituted aminopyrimidines.
Ref 529299	Bioorg Med Chem. 2008 Mar 15;16(6):2741-52. Epub 2008 Jan 12.A new generation of adenosine receptor antagonists: from di- to trisubstituted aminopyrimidines.

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Drug Information