Drug Information

Drug General Information
Drug ID
D0H6KD
Former ID
DIB018154
Drug Name
[125I]GTI
Synonyms
serotonin-5-O-carboxymethyl-glycyl-(125I)tyrosinamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526734]
Structure
Download
2D MOL
Formula
C23H26IN5O5
InChI
InChI=1S/C23H26IN5O5/c24-17-7-13(1-4-20(17)30)8-19(23(26)33)29-21(31)11-28-22(32)12-34-15-2-3-18-16(9-15)14(5-6-25)10-27-18/h1-4,7,9-10,19,27,30H,5-6,8,11-12,25H2,(H2,26,33)(H,28,32)(H,29,31)/t19-/m0/s1/i24-2
InChIKey
JVQSCVCNDUJMMW-BYWNROPASA-N
PubChem Compound ID
73755035
PubChem Substance ID
135651108
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Agonist [533994]
5-hydroxytryptamine 1D receptor Target Info Agonist [533994]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signaling
References
Ref 526734Direct visualization of serotonin1D receptors in the human brain using a new iodinated radioligand. Brain Res Mol Brain Res. 1992 Mar;13(1-2):175-8.
Ref 533994Autoradiographic characterisation and localisation of 5-HT1D compared to 5-HT1B binding sites in rat brain. Naunyn Schmiedebergs Arch Pharmacol. 1993 Jun;347(6):569-82.

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