Drug General Information
Drug ID	D0H6OS
Former ID	DNC004248
Drug Name	Geldanamycin-estradiol hybrid
Indication	Discovery agent		Investigative	[525501]
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	mRNA of HER2	Target Info	Inhibitor	[525501]
	Estrogen receptor beta	Target Info	Inhibitor	[525501]
	Heat shock protein HSP 90	Target Info	Inhibitor	[525501]
	Estrogen receptor	Target Info	Inhibitor	[525501]
	Heat shock protein HSP90	Target Info	Inhibitor	[525501]
KEGG Pathway	ErbB signaling pathway
	Calcium signaling pathway
	HIF-1 signaling pathway
	Focal adhesion
	Adherens junction
	Pathways in cancer
	Proteoglycans in cancer
	MicroRNAs in cancer
	Pancreatic cancer
	Endometrial cancer
	Prostate cancer
	Bladder cancer
	Non-small cell lung cancer
	Central carbon metabolism in cancerhsa04915:Estrogen signaling pathway
	Prolactin signaling pathwayhsa04141:Protein processing in endoplasmic reticulum
	PI3K-Akt signaling pathway
	Antigen processing and presentation
	NOD-like receptor signaling pathway
	Progesterone-mediated oocyte maturation
	Estrogen signaling pathway
	Prostate cancerhsa04915:Estrogen signaling pathway
	Prolactin signaling pathway
	Thyroid hormone signaling pathway
	Endocrine and other factor-regulated calcium reabsorption
NetPath Pathway	TCR Signaling PathwayNetPath_14:IL2 Signaling Pathway
	TCR Signaling PathwayNetPath_25:FSH Signaling Pathway
	EGFR1 Signaling Pathway
	RANKL Signaling Pathway
PANTHER Pathway	Cadherin signaling pathway
	EGF receptor signaling pathway
Pathway Interaction Database	ErbB4 signaling events
	ErbB2/ErbB3 signaling events
	ErbB receptor signaling network
	a6b1 and a6b4 Integrin signaling
	Validated targets of C-MYC transcriptional repressioner_nongenomic_pathway:Plasma membrane estrogen receptor signaling
	Validated nuclear estrogen receptor beta network
	Validated nuclear estrogen receptor alpha networkhdac_classii_pathway:Signaling events mediated by HDAC Class II
	Validated targets of C-MYC transcriptional activation
	Integrin-linked kinase signaling
	LKB1 signaling events
	Regulation of Telomerase
	Glucocorticoid receptor regulatory network
	Class I PI3K signaling events
	IL2 signaling events mediated by PI3K
	Regulation of Androgen receptor activity
	Integrins in angiogenesis
	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
	VEGFR1 specific signals
	Signaling events mediated by VEGFR1 and VEGFR2
	Class I PI3K signaling events mediated by Aktsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
	Signaling events mediated by HDAC Class II
	Plasma membrane estrogen receptor signaling
	ATF-2 transcription factor network
	AP-1 transcription factor network
	FOXM1 transcription factor network
	Validated nuclear estrogen receptor alpha network
	Signaling mediated by p38-alpha and p38-beta
	FOXA1 transcription factor network
PathWhiz Pathway	Phosphatidylinositol Phosphate Metabolism
Reactome	SHC1 events in ERBB2 signaling
	PLCG1 events in ERBB2 signaling
	PIP3 activates AKT signaling
	GRB2 events in ERBB2 signaling
	PI3K events in ERBB2 signaling
	Constitutive Signaling by Aberrant PI3K in Cancer
	Sema4D induced cell migration and growth-cone collapse
	RAF/MAP kinase cascadeR-HSA-383280:Nuclear Receptor transcription pathwayR-HSA-1236382:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
	Regulation of actin dynamics for phagocytic cup formation
	eNOS activation
	Regulation of PLK1 Activity at G2/M Transition
	Attenuation phase
	HSF1-dependent transactivation
	Loss of Nlp from mitotic centrosomes
	Recruitment of mitotic centrosome proteins and complexes
	Loss of proteins required for interphase microtubule organization?from the centrosome
	EPHA-mediated growth cone collapse
	VEGFA-VEGFR2 Pathway
	VEGFR2 mediated vascular permeability
	Anchoring of the basal body to the plasma membrane
	Constitutive Signaling by EGFRvIIIR-HSA-1251985:Nuclear signaling by ERBB4
	Nuclear Receptor transcription pathway
WikiPathways	DNA Damage Response (only ATM dependent)
	ErbB Signaling Pathway
	EGF/EGFR Signaling Pathway
	Extracellular vesicle-mediated signaling in recipient cells
	Bladder Cancer
	Signaling by ERBB2
	Integrated Pancreatic Cancer Pathway
	Signaling Pathways in Glioblastoma
	Leptin signaling pathway
	miR-targeted genes in muscle cell - TarBase
	Semaphorin interactionsWP706:SIDS Susceptibility Pathways
	Ovarian Infertility Genes
	Nuclear ReceptorsWP2884:NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Aryl Hydrocarbon Receptor Pathway
	Binding and Uptake of Ligands by Scavenger Receptors
	Fcgamma receptor (FCGR) dependent phagocytosis
	Influenza Life Cycle
	EBV LMP1 signaling
	Aryl Hydrocarbon Receptor
	Corticotropin-releasing hormone
	TNF alpha Signaling Pathway
	Arylhydrocarbon receptor (AhR) signaling pathway
	Signaling by EGFR
	Semaphorin interactions
	Mitotic G2-G2/M phases
	Metabolism of nitric oxide
	NOD pathwayWP712:Estrogen signaling pathway
	Estrogen Receptor Pathway
	Signaling by ERBB4
	JAK/STAT
	Integrated Breast Cancer Pathway
	Nuclear Receptors
References
Ref 525501	Bioorg Med Chem Lett. 1999 May 3;9(9):1233-8.Synthesis and evaluation of geldanamycin-estradiol hybrids.
Ref 525501	Bioorg Med Chem Lett. 1999 May 3;9(9):1233-8.Synthesis and evaluation of geldanamycin-estradiol hybrids.

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