Drug Information

Drug General Information
Drug ID
D0H6YF
Former ID
DIB018557
Drug Name
2-iodo-melatonin
Synonyms
2-iodomelatonin; 2-I-MLT
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538820]
Structure
Download
2D MOL

3D MOL
Formula
C13H15IN2O2
InChI
InChI=1S/C13H15IN2O2/c1-8(17)15-6-5-10-11-7-9(18-2)3-4-12(11)16-13(10)14/h3-4,7,16H,5-6H2,1-2H3,(H,15,17)
InChIKey
FJDDSMSDZHURBJ-UHFFFAOYSA-N
PubChem Compound ID
115348
PubChem Substance ID
4501994, 10236748, 11111317, 11113672, 14925812, 17405172, 26751858, 29296844, 47276710, 47276711, 47870806, 49859761, 50139481, 50139486, 53777716, 57339130, 79348311, 81055040, 85087006, 85208909, 85788614, 91746217, 92304012, 99444661, 103205947, 103837751, 104398177, 117539624, 124749855, 124880415, 124880416, 125713001, 126726217, 127854796, 134222428, 134341338, 135072530, 135651396, 135697865, 140308831, 142167520, 160969243, 162022733, 163129227, 179293782, 196372197, 226526019, 241176901, 241181856, 241377456
Target and Pathway
Target(s) Melatonin receptor Target Info Agonist [533401]
KEGG Pathway Neuroactive ligand-receptor interaction
Circadian entrainment
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 538820(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1343).
Ref 533401Characterization of a retinal melatonin receptor. J Pharmacol Exp Ther. 1985 Aug;234(2):395-401.

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