Drug Information

Drug General Information
Drug ID
D0H7AC
Former ID
DCL001076
Drug Name
PF-03814735
Drug Type
Small molecular drug
Indication Advanced solid tumor [ICD9: 140-199; ICD10:C00-C75, C7A, C7B] Discontinued in Phase 1 [548451]
Company
Pfizer
Structure
Download
2D MOL

3D MOL
Formula
C23H25F3N6O2
Canonical SMILES
CC(=O)NCC(=O)N1C2CCC1C3=C2C=CC(=C3)NC4=NC=C(C(=N4)NC5CC<br />C5)C(F)(F)F
InChI
1S/C23H25F3N6O2/c1-12(33)27-11-20(34)32-18-7-8-19(32)16-9-14(5-6-15(16)18)30-22-28-10-17(23(24,25)26)21(31-22)29-13-3-2-4-13/h5-6,9-10,13,18-19H,2-4,7-8,11H2,1H3,(H,27,33)(H2,28,29,30,31)
InChIKey
RYYNGWLOYLRZLK-UHFFFAOYSA-N
PubChem Compound ID
49830590
PubChem Substance ID
103904739, 121131499, 123055411, 134339472, 136348842, 136946498, 162011618, 162038120, 164194003, 172918088, 181688831, 223705292, 242521328, 252216036
Target and Pathway
Target(s) Aurora kinase A Target Info Inhibitor [537564]
Aurora kinase B Target Info Inhibitor [537564]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 548451Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025628)
Ref 537564Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66.

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