Drug General Information
Drug ID
D0H7GQ
Former ID
DCL000899
Drug Name
NS 1209
Drug Type
Small molecular drug
Indication Epilepsy; Neuropathic pain [ICD9: 356.0, 356.8; ICD10:G40, G64, G90.0] Phase 2 [530030], [536498]
Therapeutic Class
Analgesics
Company
NeuroSearch
Structure
Download
2D MOL

3D MOL

Formula
C24H28N4O7S
Canonical SMILES
CN1CCC2=C(C1)C3=NC(=O)C(=C3C=C2C4=CC=C(C=C4)S(=O)(=O)N(<br />C)C)NOC(CCO)C(=O)O
InChI
1S/C24H28N4O7S/c1-27(2)36(33,34)15-6-4-14(5-7-15)17-12-18-21(19-13-28(3)10-8-16(17)19)25-23(30)22(18)26-35-20(9-11-29)24(31)32/h4-7,12,20,29H,8-11,13H2,1-3H3,(H,31,32)(H,25,26,30)
InChIKey
CFJRSKULEDUDKL-UHFFFAOYSA-N
CAS Number
CAS 205645-02-9
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Glutamate receptor, ionotropic kainate 1 Target Info Modulator [530030]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
PANTHER Pathway Huntington disease
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
References
Ref 530030The efficacy of the AMPA receptor antagonist NS1209 and lidocaine in nerve injury pain: a randomized, double-blind, placebo-controlled, three-way crossover study. Anesth Analg. 2009 Apr;108(4):1311-9.
Ref 536498Emerging drugs for epilepsy. Expert Opin Emerg Drugs. 2007 Sep;12(3):407-22.
Ref 530030The efficacy of the AMPA receptor antagonist NS1209 and lidocaine in nerve injury pain: a randomized, double-blind, placebo-controlled, three-way crossover study. Anesth Analg. 2009 Apr;108(4):1311-9.

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